|Description||Nucleophosmin rabbit polyclonal|
|Protein full name||Nucleophosmin|
|Synonyms||NPM, Nucleolar phosphoprotein B23, Npm1, Nucleolar protein NO38, Numatrin|
|Immunogen||KLH conjugated Synthetic peptide
corresponding to Mouse Nucleophosmin
|Predicted MW.||33 kDa|
|Observed MW.||38 kDa|
|Uniprot ID||P06748, Q61937, P13084|
|WB||Human, Mouse, Rat||1: 500-1: 1000||spleen, testis|
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.
Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1endonuclease activity on apurinic/apyrimidinic double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication.
Western blot analysis of Nucleophosmin (GB121043) at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: MCF7 cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: PC12 cell lysate
Lane 6: Mouse spleen tissue lysate
Lane 7: Mouse testis tissue lysate
Lane 8: Rat spleen tissue lysate
Lane 9: Rat testis tissue lysate
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.|
|Storage Buffer||PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.|
NOTE: This product is intended for research only.