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Anti -Nucleophosmin Rabbit pAb

貨號:GB121043

品牌:Servicebio

價格:¥650

規格: 100 μl

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Product Information

 

Description Nucleophosmin rabbit polyclonal
Protein full name Nucleophosmin
Synonyms NPM, Nucleolar phosphoprotein B23, Npm1, Nucleolar protein NO38, Numatrin
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse Nucleophosmin
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Predicted MW. 33 kDa
Observed MW. 38 kDa
Uniprot ID P06748, Q61937, P13084

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Human, Mouse, Rat 1: 500-1: 1000 spleen, testis

 


 

Background
 

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. 
Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1endonuclease activity on apurinic/apyrimidinic double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. 

 


 

Images

 


Western blot analysis of Nucleophosmin (GB121043) at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: MCF7 cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: PC12 cell lysate
Lane 6: Mouse spleen tissue lysate
Lane 7: Mouse testis tissue lysate
Lane 8: Rat spleen tissue lysate
Lane 9: Rat testis tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.
 

 

NOTE: This product is intended for research only.

 

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